I tried all of the usual tricks. Unplugging and re-plugging the mouse’s USB adapter didn’t work. Neither did changing the scroll wheel setting in Logitech Options. Clicking the mouse’s wheel motion button to switch from clicking to smooth didn’t fix it either. After spending an inordinate amount of time searching on Google I discovered that one of macOS Mojave’s new features, designed to provide more security, was instead wrecking my scrolling. In this support article on Logitech’s (opens in new tab) site, I found out that “Accessibility access is needed for scrolling, gesture button, back/forward, zoom and several other features,” which explained my mouse couldn’t activate Mission Control with the thumb button I mapped to Gesture. MacOS is supposed to present you with a system prompt when you first try and activate one of these features, but I guess I ignored the option and moved along. Here’s how to enable Logitech mouse functionality (as well as any other similarly broken features.)

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  1. Click the Apple logo.
  2. Select System Preferences.
  3. Click Security & Privacy.
  4. Click Privacy.
  5. Select Accessibility. 
  6. Click the lock and enter your password.
  7. Check the box next to Logitech Options Daemon. Accessibility access can also be necessary for other system access-demanding applications, such as Chrome Remote Desktop, Steam and Bartender. Credit: Laptop Mag

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